What is D-Mannose powder and how does it work

In this post, I explain when and how D-Mannose powder works in your body and when it doesn’t work.

E. coli and D-Mannose

Apparently, E. coli bacteria that causes 90% of all urinary tract infections, adheres to the sugar (mannose) that is naturally available on your bladder walls. Yes, the bacteria have a “sweet tooth”! Once they are stuck to the bladder lining, nothing can peel them off. That’s why just drinking water is not helpful. Therefore, traditionally the next step is to kill those harmful E. coli with antibiotics.

However, when D-mannose is available in abundance in urine, E. coli will “go” after it and “let go” of your bladder walls.

As soon as the bacteria are re-attached to the free-floating D-Mannose they are quickly flushed away during urination. The remainder is killed by your white blood cells and other immune cells. Because of the D-Mannose molecule’s ability to circulate throughout the urinary tract, they can even help eliminate E. coli attached to the prostate gland.

D-Mannose in your body

D-Mannose is a monosaccharide, a simple sugar but unlike glucose, your body absorbs D-Mannose eight times slower.

Because it is hard for our bodies to absorb D-Mannose, it passes straight to the bloodstream, then through the kidneys into the bladder. Your body does not metabolize D-Mannose like other sugars, and that’s why D-Mannose powder does not affect the blood sugar levels, and therefore is safe for the diabetics and does not cause weight gain.

D-Mannose does not kill the bacteria and therefore does not increase its resistance. Many pharmaceutical companies nowadays are trying to develop a drug to target those hooks that E. coli uses to hold on to the mannose of your bladder.

Infographic: how does d-mannose work?

D-Mannose powder is a natural remedy

D-mannose powder is truly wonderful:

  • It has no serious side effects (read about most frequent D-Mannose side effects).
  • It will not destroy your other friendly bacteria.
  • It will not cause allergic reactions.
  • It is safe for most people.

D-Mannose is found in cranberries and blueberries, peaches, apples, and oranges but its natural concentration is low. You would need to consume tons of fruit to reach needed levels of D-Mannose in your urine. In comparison, you need just a teaspoon per dose if you are using D-Mannose powder.

FDA disclaimer

Some think, that if used early enough D-mannose can cure UTI without antibiotics. These claims have not been confirmed clinically and FDA does not regulate production and formulation of D-Mannose powder. It might work for you, but there is always a chance that it won’t. So make sure to watch your symptoms and go to the doctor if you see no improvement. Self-treating a UTI could be a very dangerous thing!

If you are interested I invite you to research the work of Dr. Jonathan V. Wright on this topic and read reviews from other UTI stragglers on Amazon.

If you bought D-Mannose already, here read my post about the D-Mannose dose for UTI and how to take D-Mannose.

D-Mannose powder sources

Some manufacturers use birch tree juices to produce the D-Mannose powder. Majority manufacture it from corn.

The process to extract D-Mannose consists of two steps: first is to use a strong light to charge the ions of mannose in the sugary juice collected from the plants till D-Mannose sticks to a collector plate; second is to scrape off the sugar.

D-Mannose can be also produced in a lab. It is easy to recognize synthetic D-Mannose because it won’t dissolve in water completely leaving a chalky white mixture on the bottom of the glass. Synthetic D-Mannose is not manufactured the same way as natural D-Mannose and some think that it’s less effective than the natural one.

Natural D-Mannose powder is frequently made from birch trees’ sap

Natural D-Mannose frequently made from birch trees' sap!
Natural D-Mannose frequently made from birch trees’ sap!

Three things to consider before you decide to try D-Mannose

1) Can you overnight it from Amazon or do you live nearby Whole foods market or Sprouts or some alternative medicine pharmacy? D-Mannose is easier to find in retail if you live in a big city.

2) Do you have any additional issues with bladder or kidneys? If yes, you could have been developing the infection for longer than you know. Do not risk a complication! You can try D-Mannose in the early stages only and if you have no other health problems.

3) You might be in that 10 % of sufferers who have UTI caused by some other (not E. coli) bacteria and D-Mannose will not help. It could be an STD. Make sure you know your diagnosis before you attempt a self-treatment protocol.

My experience

Read about my experience of treating UTI with D-Mannose for a first-hand account.

UTIs are so painful and unfortunately also popular. D-Mannose seems to have no complications so it is low risk to try. If it helped you or others I would be happy to know!

What did I do when I had my UTIs and how did I stop them from reoccurring? I share my story here.

Where to buy D-Mannose powder

I suggest you buy it in powder form because it is easier to portion and you do not need to waste your money on capsules.

1) Your local Whole Foods market or any other supermarket or a pharmacy that sells natural remedies.

2) Amazon (or any other internet retailer):

Here are two very popular products:

  1. BulkSupplements Pure D-mannose Powder (250 grams)
  2. D-mannose 500 mg – 120 Caps

If you buy it, please take a minute to write me back about your experience with the product.

Best wishes and stay healthy!

18 thoughts on “What is D-Mannose powder and how does it work”

  1. Pingback: Ultimate Review of Bladder Health Supplements, 2018 (updated) - Stop UTI forever

  2. So happy to find this information. My 22 year old daughter gets uti’s very frequently and so severe that she passes blood and is confined to the toilet until the antibiotics start to work. It is debilitating. I will be sharing this info with her. I am positive it is due to e coli bacteria as she has been to see a urologist to rule out any structural causes.

  3. Anastasia Madam,
    My elderly mother aged 68 years is bed ridden since last 4 years on account of intertrochanteric fracture (which was not operated upon) and Parkinsonism and also suffers from diabetes, hypertension, recurrent MDR UTI, hypothyroidism and dementia. Last month she was hospitalised for 20 days due to lung infection, UTI and bed sores. Subsequently, she is on oxygen requirement of 1 lpm and catheterized subsequently. As I write this, she again got admitted in hospital 2 days back due to high fever and possible UTI. She is suffering from UTI again and again. Can I use D mannose powder to prevent her recurrent UTI and what should be the appropriate dosage? As I am the sole caretaker, frequent visits to hospital since last 4 years have left me emotionally and financially drained out.
    Can you suggest a way out?

    1. Hi Ashutosh, I’m sorry to hear, this sounds like a tough situation, sounds like you are doing everything to help her. She has a lot going on. First of all, I’d recommend just checking with nursing staff to remove the catheter as soon as it is not needed. Every extra day increases her chances to re-infect. I know you mentioned financial struggles but here is a new (yet, expensive) medication you can ask your doctor about (perhaps, insurance can cover), it’s called Ellura.
      Here is a post we wrote about UTI in elderly but your case is definitely a complicated one. The thing is, with UTIs like she has, there is a high chance that it’s caused by more than one pathogen, you can confirm this with the nurses at the hospital, they should have her lab results. If it’s juts E.coli, check with them if you could give your mom 1/2 of a teaspoon of D-Mannose in water or tea, once a day (this is a standard dose recommended by most manufacturers). A possible side-effect is diarrhea, although probably unlikely for a small dose, but make sure to check with the nurses first, I’m sure they’ve heard about D-Mannose.
      Also, if they put your mom on preventive Macrobid, watch out for any lung function impairment. Best wishes,

    2. First, I want to say so sorry for your mother’s health. My mother-in-law passed last year with similar conditions. Being a registered nurse, I see this situation quite often. More than likely, your mother’s MDRO causing her UTI’s is more than one organism. What I read from the information above, D-mannose is only effective on E. coli., which is probably the largest contributor. There are other gut flora that can cause UTI’s, such as K. pneumoniae and P. mirabilis. The latter two bacteria would not be affected. Seems like it would not hurt to try and keep the E. coli bacteria count down. At some point, she will be bacteria colonization, meaning she will always have the MDRO in her urine, but only treated if symptoms are present: pain, burning with urination, fever, etc. Being that D-mannose are larger particles being filtered by the renal system, I would check with her Nephrologist/Urologist just to be on the safe side.

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