Review of bladder health supplements

Ultimate Review of Bladder Health Supplements, 2019 (updated)

Bladder health supplements could play an important role in helping you treat and prevent urinary tract infections. In this post, I will review the most popular bladder health supplements that you can use if you suffer from chronic urinary tract infections. Many have been available on the market for a while and some new ones are just getting traction in 2019. 

Important disclaimer: Always consult with your physician before starting on a new supplement. Even though most supplements are safe, they still can interfere with your other meds or provoke an allergic reaction. Also, remember, that clinical research cited in this review was performed on otherwise healthy, not pregnant adults. Supplements by definition are not intended to prevent or treat any diseases, however, they can boost your existing prevention or treatment strategy.

In this review, I divide bladder health supplements for chronic UTI into four main categories:

    1. Bladder health supplements that promote healing of bladder lining
    2. Bladder health supplements that alkalize the urine
    3. Bladder health supplements that help to decrease the number of harmful bacteria in your urinary tract
    4. Supplements that help to increase the number of beneficial bacteria. 

Bladder health supplements that promote healing of bladder lining: mucopolysaccharides

Healthy bladder urothelium (first layer of bladder lining) has a high density of glycosaminoglycans, which are present in the form of proteoglycans, and form the so-called ‘GAG layer’. GAG layer serves as a barrier layer on the inner surface of the bladder.

Urinary tract infections cause inflammation of bladder lining. After multiple UTIs, your bladder lining is much different than the one of a healthy person who never had a UTI. Bladder urothelium of a chronic UTI sufferer could be eroded, thinner than normal, and ulcerated.

Damaged GAG layer fails to protect you from pathogenic bacteria that are able to hide in deeper layers of the bladder lining. Moreover, toxic substances contained in urine can irritate and cause further inflammation of the bladder wall when it is not shielded by healthy urothelium. 

Chronic bladder inflammation could be one of the reasons why it is common for women who have no acute infection to still experience bladder discomfort, often aggravated by bladder filling and relieved with voiding. Many chronic UTI sufferers report bladder pain or pressure, urgency and frequency even though their tests are absent from acute infection.

Therefore, if you suffer from chronic bladder pains you might benefit from using supplements that contain glycosaminoglycans (GAGs). These supplements could potentially benefit an inflamed bladder by replenishing the defective GAG layer.

Naturally occurring mucopolysaccharides are hyaluronic acid, chondroitin sulfate, bioflavinoid quercitin, and aloe vera.

Hyaluronic acid

Using Hyaluronic acid to replenish the GAG layer is a newer promising strategy proposed for patients with chronic bladder inflammation. I came across hundreds of studies that demonstrate the effectiveness of Hyaluronic acid for a variety of bladder-related diagnoses.

However, all clinical tests that have been performed using Hyaluronic acid were done via direct bladder installations, meaning cocktails with Hyaluronic acid were put directly into the bladder. If you are not planning to put a needle or a catheter in your bladder, supplements in a form of capsules might do the trick.

In fact, a 2018 clinical study used a combination of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin orally and showed promising results in reducing urgency and frequency of UTI after sex among women who took the supplements every day.

According to hundreds of reviews online, the Hyaluronic acid in capsules helps sufferers around the world to improve the condition of their joints and skin. One could hope that in a similar fashion it could help to rebuild healthy bladder lining and elevate symptoms of those who suffer from chronic UTIs and Interstitial cystitis (IC) (which is basically chronic inflammatory bladder)

Bladder health supplements containing Hyaluronic acid (least expensive per serving first):

Chondroitin sulfate

Similar to Hyaluronic acid, Chondroitin sulfate helps to restore the bladder’s epithelium and promote healing from bladder inflammation. Chondroitin sulfate is the main ingredient in bladder health supplements such as in Cystoprotek and Cysto renew capsules known in the IC community.

However, similar to Hyaluronic acid, in the few studies that showed the effectiveness of Chondroitin sulfate, the drug administration was done intravesically (straight into the bladder). It is unclear if Chondroitin sulfate will work well when taken orally but I think there is no harm in trying. You can go with pure Chondroitin sulfate or choose to try one of the formulas packed with additional health-boosting elements, such as Aloe vera. 

Bladder health supplements containing Chondroitin sulfate (least expensive per serving first):

Aloe Vera Juice

For ages, Aloe vera plant has been known for it’s antiinflammatory and wound healing properties. To no surprise, many naturopathic doctors advise taking Aloe vera juice to help to heal bladder lining and reduce inflammation, especially after acute infections.

Some patients diagnosed with interstitial cystitis (IC) report significant relief in symptoms within 2-3 weeks after starting a therapy with juice or capsules taken on a daily basis. As with all supplements, do not look for immediate relief and make sure to adjust your diet to promote the health of your bladder. 

You can choose to drink Aloe vera juice or take capsules. Capsules have more potency and definitely easier to manage during the weeks of therapy.

Bladder health supplements containing Aloe vera (least expensive per serving first):

Quercetin

The bioflavonoid quercetin is a naturally occurring substance that has anti-inflammatory and anti-oxidant properties. It is present in seeds, citrus fruits, olive oil, tea, and red wine.

A quercetin-containing compound (called Cysta Q) was studied in 22 IC patients given 500 mg twice a day for 4 weeks. Two patients dropped out of the study. Of the remaining 20 patients, 57% had a significant decrease in symptoms. A randomized, placebo-controlled trial is needed to further determine the efficacy of quercetin in treating chronic bladder inflammation but it seems promising.

Some quercetin supplements come with bromelain derived from pineapples that may enhance quercetin absorption. However, if you are trying to minimize $$ spent and maximize the effect, you can purchase bromelain or papaya enzymes separately.

Bladder health supplements containing quercetin (least expensive per serving first):

Marshmallow Root

In the same way, marshmallow soothes sore throats, marshmallow appears to ease swelling in mucous membranes that line the colon and the urinary tract. 

Moreover, Marshmallow root has been identified as having one of the highest levels of glucuronoxylan, a potent antioxidant. Glucuronoxylan protects cells from free radical damage, promoting healthy cell regeneration. It also demonstrates mild antibacterial properties.

Remember that Marshmallow root possesses diuretic properties, encouraging urine flow (you will pee more often) so be mindful of this effect.

Bladder health supplements containing Marshmallow root (least expensive per serving first):

Bladder health supplements that alkalize the urine

New research demonstrates that alkaline urine can promote better bladder health by suppressing the growth of pathogenic bacteria. It is important to highlight that high urine pH is also a symptom of a healthy diet that is rich in greens, vegetables, and berries. There are a couple of things that happen when your diet includes a variety of veggies and greens:

First, you provide an ample supply of prebiotics for your good bacteria, creating a better environment for them to reproduce, thrive and help you to stay healthy. Especially if you are taking probiotics, it is crucial that you help your newly obtained beneficial bacteria with better diet and/or probiotics.

Second, you introduce various bioactive elements that help to fight pathogenic bacteria.

Therefore, alkaline urine is a side effect of a balanced diet. Your task is to provide your body with the right fuel so it can maintain it’s natural defenses.

If you want to eat your cake and to get all the benefits of a healthy diet, research shows that plant-based supplements can help if you are unwilling to drastically change your diet and rather spend some money and drink your veggies. 

Plant-based bladder health supplements are (least expensive per serving first): 

Bladder health supplements that help to decrease the number of harmful bacteria

D-mannose

D-Mannose is a form of sugar that could be found in fruits and berries. Most commercially produced D-Mannose is made of corn or birch tree juice.

D-Mannose can help you to reduce the number of E. coli bacteria in a safe, natural way almost without any side effects. E. coli binds to the molecules of D-Mannose and could be easily washed away with urine.

Check out this review of D-Mannose supplements.

NAC (N-acetylcysteine)

NAC is one of the most important supplements in fighting chronic infections. For several years now NAC supplements have been investigated for their effectiveness both in inhibiting biofilm formation and in destroying developed biofilms.

As per the article titled “N-acetylcysteine as a powerful molecule to destroy bacterial biofilms. A systematic review: “Biofilm is a sophisticated network of pathogens living within protective extracellular polymeric substances. Bacterial resistance and survival are greatly augmented in biofilm, so that both chemical (antibiotics, disinfectants) and biological (viruses, protists) antimicrobial agents may be ineffective to eradicate them entirely. For this reason, new pharmacological approaches are desirable, in order to prevent biofilm formation, eradicate mature pre-formed biofilms and increase the permeability of antibiotics, so overcoming the resistance phenomenon.”

NAC is often consumed together with an antibiotic or an antibacterial supplement but could be also taken on its own.

600 mg twice a day is a sufficient dose to provide help in destroying bacterial biofilms and therefore helping to get rid of stubborn infections.

The jury is still out, but encouraging study results provide hope. NACs have no known side effects or contraindications (one of the studies successfully used it for treatment of pregnant women) and therefore could be a great supplement to have in your toolkit.

NAC supplements:

Garlic

E. coli bacteria that causes most of the urinary tract infections is known to form bacterial biofilms, a form of defense against the immune system and antibiotics, that’s why it is so hard to eradicate. 

Garlic has a wide range of pharmacological activities and a broad antibacterial spectrum. Moreover, allicin, isolated from garlic essential oil, has demonstrated potency against bacterial biofilms.

Use of garlic softgel tablets (serving size 2 softgels: garlic oil 4.6 mg, 500: 1 concentrate equal to 2300 mg fresh garlic), 2-4 tablets per day, together with other supplements, could be an alternative option to prevent chronic UTI and improve IC symptoms as demonstrated in a two case study.

Read more about garlic dosage for UTI.

Bladder health supplements containing garlic (least expensive per serving first):

Uva Ursi (aka Bearberry)

Uva ursi is one of the most commonly used antimicrobial botanicals for UTIs. The antimicrobial component is believed to be the aglycone hydroquinone of arbutin, which is released in alkaline urine. For optimum results, the urine pH (you can test it with urine pH strips) should be at least 8.

Increased urine alkalinity can often be achieved by a high vegetable diet; however, in some cases consumption of 6-8 g sodium bicarbonate in water daily or taking Uva ursi with calcium citrate.

Although uva ursi is commonly used successfully for UTI treatment, no studies have been conducted to confirm its efficacy. However, one clinical study indicates its effectiveness for UTI prevention. In randomized clinical study women with a history of recurrent UTI during the preceding year were assigned to take Uva Ursi supplements for a month versus placebo (those girls got a sugar pill). These women were then followed for a year to establish UTI recurrence. In placebo group 5 of 27 women experienced a UTI, while among the women who took Uva ours for one month, none had a recurrence in the following year.

Uva ursi is best used at the first sign of an infection or for short-term prophylaxis. Note in the above study the women took Uva ursi for only one month, despite the fact they were followed for one year.

Bladder health supplements with Uva Uris (least expensive per serving first)

Berberine

Berberine is a plant alkaloid with a long history of medicinal use in both Ayurvedic and Chinese medicine. It is present in many plants, including Hydrastis Canadensis (Goldenseal), Coptis Chinensis (Coptis or goldenthread), Berberis aquifolium (Oregon grape; Mahonia aquifolium), Berberis vulgaris (barberry), and Berberis aristata (tree turmeric). Berberine is found in the root, rhizome, and stem bark of the plants. Berberine extracted from Berberis aquifolium demonstrates growth inhibition of several bacteria, including both sensitive and resistant E. coli.

Do not take berberine during pregnancy.

Bladder health supplements with berberine (least expensive per serving first):

Salvia officinalis (aka Common Sage)

In an in vitro study oil of common sage inhibited several urinary pathogens extracted from urine samples provided by individuals with UTIs.

Salvia demonstrated 100-percent inhibition of Klebsiella and Enterobacter species, 96-percent inhibition of E. coli.

It is a known fact, that recurrent UTIs are caused by a combination of pathogens, therefore a supplement that can inhibit the growth of two bacteria that together cause 99% of all UTIs is critical in the prevention of recurrent infections.

Bladder health supplements with Common Sage (least expensive per serving first):

Supplements that help to increase the number of beneficial bacteria

It should come as no surprise that our bodies came equipped to protect us from harmful bacteria. However, due to many environmental factors, our own defense systems fail and sometimes requires supplementation to restore and maintain it.

Healthy human microbiome (a collection of thousands of beneficial bacteria living on and in our body) is of the critical factors in our natural defense against disease. Taking probiotics helps to restore the balance of good bacteria.

Probiotics

There are several strains that have been studied for their effectiveness against recurrent UTIs.

Probiotics work in three main ways when it comes to UTI prevention:

    1. Increased number of good bacteria in your gut allows for better nutrient and vitamin production, that in return improves how our body functions and resists infection
    2. Healthy vaginal flora helps to prevent pathogenic bacteria from reaching urinary tract
    3. Healthy flora in your bladder helps you to fight pathogenic bacteria.

To understand how to choose right probiotic strains that demonstrated clinical effectiveness in prevention of urinary tract infections, check out Probiotics & UTI: what do you need to know.

What other supplements are you taking to prevent UTIs? Leave me a comment!

53 thoughts on “Ultimate Review of Bladder Health Supplements, 2019 (updated)”

  1. Thank you for this amazing review of potential treatments. I have never been formally diagnosed with IC, but have no doubt that I have it. I had about seven years of remission it is back again after starting hormone replacement therapy. I only took them for 3 weeks but am left in a flare. Have you come across this connection before?

    1. Susan, IC is a whole big topic on its own, try ichelp.org, this is a resource focused on IC. At the same time, all processes in your body are interconnected, so I would not be surprised. Best wishes,

  2. Bonjour from France Anastasia!
    about alcalin diet, I was wondering what is best: eating alkalin food or alkaline forming food? There are a lot of different tables out on the net and none is the same as apparently some acid food turns out alkalin in the body.
    Has anybody got an idea?
    All the best,
    Magali

    1. Hi Magali, 🙂
      Yes, here are some details on UTI preventing diet . Basically, it’s not only pH but all the microelements that you get from fruits and veggies that matter. It just so happens that a healthy vegetarian diet is also alkaline to the body. I’d focus on eating fresh raw veggies and berries as much as possible, and if you feel that citrus produce negative symptoms in you, then stay away regardless whether they alkalize your urine or not 🙂

  3. Do you think it’s possible for uti’s after sex to ever go away? I inevitably get a UTI every time after sex…have tried everything. I just kind of want some hope that someone has experienced this and found a solution.

  4. Hi Anastasia,

    Your website has been a beacon for me during a rather trying time, health wise. I appreciate all of the hard work that must go into keeping this website up to date with current and relevant information on UT and Bladder health.

    I recently had a UTI and although I was diagnosed by a proper urine culture and took the full course of my antibiotics, and I am still suffering from lingering symptoms, almost 2 months later. I have repeated 3 urine cultures, which all come back negative, the pain hasn’t gotten worse, the urgency and frequency feeling has subsided, there is no blood in my urine, and it doesn’t feel like razor blades when urinating, however I don’t feel fully healed. I still have some pelvic pain coupled with a persistent burning feeling. It’s almost as if my bladder is spasming. Could it be possible that the lining of my bladder isn’t fully healed? And if so, which would you recommend I look into with respect to helping heal the lining: the hyaluronic acid or the chondroitin sulfate? Can these be taken together?

    I do have a cystoscopy booked but its close to 3 months away and I’m not sure I can wait that long for them to try and provide a solution for me. I want to be proactive and try and find a more natural, balanced approach to resolving this, if possible. Any and all insight would be greatly appreciated.

    1. Hi Cali, thank you for your kind words 🙂
      I have a great post for you here: took antibiotics so why my symptoms still linger.
      As to the supplements, I honestly wouldn’t be in a position to recommend, once you read the post you know as much as I do about those two options. When researching for this post, I came through multiple anecdotal and small clinical based case reports that were also very positive about aloe vera supplementation. As far as I know, all of the above is safe to experiment with, but your physician should be able to direct you further. Chondroitin and aloe vera are popular supplements with a good track record. I’d also encourage you to look into your diet 🙂 Best wishes,

  5. Thank you so much for this post!! I have a nasty UTI and one kidney. Until I get my insurance back I needed some relief! I’ve been searching the internet for something I haven’t already tried. I’m just so done feeling ill…

    1. Uh-oh… I wish you the best, but also please be very careful self-treating. If I were you, I’d rather go for antibiotics and then focus on prevention and healing. I shared a link to a service that provides very affordable consultations and antibiotic prescriptions if you are in USA (check here). Best wishes,

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