Ultimate Review of Bladder Health Supplements, 2017

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Bladder health supplements could play an important role in helping you treat and prevent urinary tract infections. In this post I will review most popular bladder health supplements that you can use if you suffer from chronic urinary tract infections. Many have been available on the market for a while and some new ones are just getting traction in 2017. 

Important disclaimer: Always consult with your physician before starting on a new supplement. Even though most supplements are safe, they still can interfere with your other meds or provoke an allergic reaction. Also, remember, that clinical research cited in this review was performed on otherwise healthy, not pregnant adults. Supplements by definition are not intended to prevent or treat any diseases, however they can boost your existing prevention or treatment strategy.

In this review I divide bladder health supplements for chronic UTI in four main categories:

  1. Bladder health supplements that promote healing of bladder lining
  2. Bladder health supplements that alkalize urine 
  3. Bladder health supplements that help to decrease amount of harmful bacteria in your urinary tract
  4. Supplements that help to increase amount of beneficial bacteria 

Bladder health supplements that promote healing of bladder lining: mucopolysacchrides

Healthy bladder urothelium (first layer of bladder lining) has a high density of glycosaminoglycans, which are present in the form of proteoglycans, and form the so-called ‘GAG layer’. GAG layer serves as a barrier layer on the inner surface of the bladder.

Urinary tract infections cause inflammation of bladder lining. After multiple UTIs your bladder lining is much different than the one of a healthy person who never had a UTI. Bladder urothelium of a chronic UTI sufferer could be eroded, thinner than normal, and ulcerated.

Damaged GAG layer fails to protect you from pathogenic bacteria that are able to hide in deeper layers of bladder lining. Moreover, toxic substances contained in urine can irritate and cause further inflammation of the bladder wall when it is not shield by healthy urothelium. 

Aloe - Natural Bladder Health Supplements
Aloe – Natural Bladder Health Supplement

Chronic bladder inflammation could be one of the reasons why it is common for women who have no acute infection to still experience bladder discomfort, often aggravated with bladder filling and relieved with voiding. Many chronic UTI sufferers report bladder pain or pressure, urgency and frequency even though their tests are absent of acute infection.

Therefore, if you suffer from chronic bladder pains you might benefit from using supplements that contain glycosaminoglycans (GAGs). These supplements could potentially benefit an inflamed bladder by replenishing the defective GAG layer.

Naturally occurring mucopolysaccharides are: hyaluronic acid, chondroitin sulfate, bioflavinoid quercitin, and aloe vera.

Hyaluronic acid

Using Hyaluronic acid to replenish GAG layer is a newer promising strategy proposed for patients with chronic bladder inflammation. I came across hundreds of studies  that demonstrate effectiveness of Hyaluronic acid for variety of bladder related diagnoses.

However, all clinical tests that have been performed using Hyaluronic acid were done via direct bladder installations, meaning cocktails with Hyaluronic acid were put directly into the bladder. If you are not planning to put a needle or a catheter in your bladder, supplements in a form of capsules might do the trick.

According to hundreds reviews online, Hyaluronic acid in capsules helps sufferers around the world to improve condition of their joints and skin. One could hope that in a similar fashion it could help to rebuild healthy bladder lining and elevate symptoms of those who suffer from chronic UTIs and Interstitial cystitis (IC) (which is basically chronic inflammatory bladder)

Bladder health supplements containing Hyaluronic acid (least expensive per serving first):

Chondroitin sulfate

Similar to Hyaluronic acid, Chondroitin sulfate helps to restore bladder’s epithelium and promote healing from bladder inflammation. Chondroitin sulfate is the main ingredient in bladder health supplements such as in Cystoprotek and Cysto renew capsules known in IC community.

However, similar to Hyaluronic acid, in the few studies that showed the effectiveness of Chondroitin sulfate, the drug administration was done intravesically (straight in to the bladder). It is unclear if Chondroitin sulfate will work well when taken orally but I think there is no harm in trying. You can go with pure Chondroitin sulfate or choose to try one of the formulas packed with additional health boosting elements, such as Aloe vera. 

Bladder health supplements containing Chondroitin sulfate (least expensive per serving first):

Aloe Vera Juice

For ages Aloe vera plant has been known for it’s antiinflammatory and wound healing properties. To no surprise, many naturopathic doctors advise taking Aloe vera juice to help healing bladder lining and reduce inflammation, especially after acute infections.

Some patients diagnosed with interstitial cystitis (IC) report significant relief in symptoms within 2-3 weeks after starting a therapy with juice or capsules taken on a daily basis. As with all supplements, do not look for an immediate relief and make sure to adjust your diet to promote health of your bladder. 

You can choose to drink Aloe vera juice or take capsules. Capsules have more potency and definitely easier to manage during the weeks of therapy.

Bladder health supplements containing Aloe vera (least expensive per serving first):

Quercitin

The bioflavinoid quercitin is a naturally occurring substance that has anti-inflammatory and anti-oxidant properties. It is present in seeds, citrus fruits, olive oil, tea, and red wine.

A quercitin-containing compound (called Cysta Q) was studied in 22 IC patients given 500 mg twice a day for 4 weeks. Two patients dropped out of the study. Of the remaining 20 patients, 57% had a significant decrease in symptoms. A randomized, placebo-controlled trial is needed to further determine the efficacy of quercitin in treating chronic bladder inflammation but it seems promising.

Some quercitin supplements come with bromeline derived from pineapples that may enhance quercetin absorption. However, if you are trying to minimize $$ spent and maximize the effect, you can purchase bromeline or papaya enzymes separately.

Bladder health supplements containing quercitin (least expensive per serving first):

Marshmallow Root

In the same way marshmallow soothes sore throats, marshmallow appears to ease swelling in mucus membranes that line the colon and the urinary tract. 

Marshmallow root is great for your bladder
Marshmallow root powder is great for your bladder. But not the candied one!

Moreover, Marshmallow root has been identified as having one of the highest levels of glucuronoxylan, a potent antioxidant. Glucuronoxylan protects cells from free radical damage, promoting healthy cell regeneration. It also demonstrates mild antibacterial properties.

Remember that Marshmallow root possesses diuretic properties, encouraging urine flow (you will pee more often) so be mindful of this effect.

Bladder health supplements containing Marshmallow root (least expensive per serving first):

Bladder health supplements that alkalize urine

New research demonstrates that alkaline urine can promote better bladder health by suppressing growth of pathogenic bacteria. It is important to highlight that low urine pH is also a symptom of a healthy diet that is rich in greens, vegetables and berries. There are couple things that happen, when you diet includes a variety of veggies and greens:

Plant based prebiotics- Natural Bladder Health Supplements
Eat or drink your veggies regularly to maintain healthy urine pH

First, you provide ample supply of prebiotics for your good bacteria, creating a better environment for them to reproduce, thrive and help you to stay healthy. Especially if you are taking probiotics, it is crucial that you help your newly obtained beneficial bacteria with better diet and/or probiotics.

Second, you introduce various bio active elements that help to fight pathogenic bacteria.

Therefore, alkaline urine is a side effect of a balanced diet. Your task is to provide your body with the right fuel so it can maintain it’s natural defenses.

If you want to eat your cake and to get all the benefits of a healthy diet, research shows that plant based supplements can help if you are unwilling to drastically change your diet and rather spend some money and drink your veggies. 

Plant based bladder health supplements are (least expensive per serving first): 

Bladder health supplements that help to decrease amount of harmful bacteria

D-mannose

D-Mannose is a form of sugar that could be found in fruits and berries. Most of commercially produced D-Mannose is made of corn or birch tree juice.

D-Mannose can help you to reduce number of E. coli bacteria in a safe, natural way almost without any side effects. E. coli binds to the molecules of D-Mannose and could be easily washed away with urine.

Check out this review of D-Mannose supplements.

NAC (N-acetylcysteine)

NAC is one the most important supplements in fighting chronic infections. For several year now NAC supplements have been investigated for their effectiveness both in inhibiting biofilm formation and in destroying developed biofilms.

As per article titled “N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review”: “Biofilm is a sophisticated network of pathogens living within protective extracellular polymeric substances. Bacterial resistance and survival are greatly augmented in biofilm, so that both chemical (antibiotics, disinfectants) and biological (viruses, protists) antimicrobial agents may be ineffective to eradicate them entirely. For this reason, new pharmacological approaches are desirable, in order to prevent biofilm formation, eradicate mature pre-formed biofilms and increase the permeability of antibiotics, so overcoming the resistance phenomenon.”

NAC is often consumed together with an antibiotic or an antibacterial supplement but could be also taken on it’s own.

600 mg twice a day is a sufficient dose to provide help in destroying bacterial biofilms and therefore helping to get rid of stubborn infections.

The jury is still out, but encouraging study results provide hope. NACs have no known side effects or contraindications (one of the studies successfully used it for treatment of pregnant women) and therefore could be a great supplement to have in your toolkit.

NAC supplements:

Garlic

E. coli bacteria that causes most of urinary tract infections, is known to form bacterial biofilms, a form of defense against immune system and antibiotics, that’s why it is so hard to eradicate. 

Garlic has a wide range of pharmacological activities, and a broad antibacterial spectrum. Moreover, allicin, isolated from garlic essential oil, has demonstrated potency against bacterial biofilms.

Use of garlic softgel tablets (serving size 2 softgels: garlic oil 4.6 mg, 500 : 1 concentrate equal to 2300 mg fresh garlic), 2-4 tablets per day, together with other supplements, could be an alternative option to prevent chronic UTI and improve IC symptoms as demonstrated in a two case study.

Bladder health supplements containing garlic (least expensive per serving first):

Uva Ursi (aka Bearberry)

Uva ursi is one of the most commonly used antimicrobial botanicals for UTIs. The antimicrobial component is believed to be the aglycone hydroquinone of arbutin, which is released in alkaline urine. For optimum results, the urine pH (you can test it with urine pH strips) should be at least 8.

Increased urine alkalinity can often be achieved by a high vegetable diet; however, in some cases consumption of 6-8 g sodium bicarbonate in water daily or taking Uva ursi with calcium citrate.

Uva Ursi natural bladder health supplement
Uva Ursi is a very well known natural bladder health supplement

Although uva ursi is commonly used successfully for UTI treatment, no studies have been conducted to confirm its efficacy. However, one clinical study indicates its effectiveness for UTI prevention. In a randomized clinical study women with a history of recurrent UTI during the preceding year were assigned to take Uva ours supplements for a month a placebo. These women where then followed for a year to establish UTI recurrence. In placebo group 5 of 27 women experienced a UTI, while among the women who took Uva ours for one month, none had a recurrence in the following year.

Uva ursi is best used at the first sign of an infection or for short-term prophylaxis. Note in the above study the women took Uva ursi for only one month, despite the fact they were followed for one year.

Bladder health supplements with Uva Uris (least expensive per serving first)

Berberine

Berberine is a plant alkaloid with a long history of medicinal use in both Ayurvedic and Chinese medicine. It is present in many plants, including Hydrastis canadensis (goldenseal), Coptis chinensis (Coptis or goldenthread), Berberis aquifolium (Oregon grape; Mahonia aquifolium), Berberis vulgaris (barberry), and Berberis aristata (tree turmeric). Berberine is found in the root, rhizome, and stem bark of the plants. Berberine extracted from Berberis aquifolium demonstrates growth inhibition of several bacteria, including both sensitive and resistant E. coli.

Do not take berberine during pregnancy.

Bladder health supplements with berberine (least expensive per serving first):

Salvia officinalis (aka Common Sage)

In an in vitro study oil of common sage inhibited several urinary pathogens extracted from urine samples provided by individuals with UTIs.

Salvia demonstrated 100-percent inhibition of Klebsiella and Enterobacter species, 96-percent inhibition of E. coli.

It is a known fact, that recurrent UTIs are caused by combination of pathogens, therefore a supplement that can inhibit growth of two bacteria that together cause 99% of all UTIs is critical in prevention of recurrent infections.

Bladder health supplements with Common Sage (least expensive per serving first):

Supplements that help to increase amount of beneficial bacteria

It should come to no surprise that our bodies came equipped to protect us from harmful bacteria. However, due to many environmental factors our own defense systems fails and sometimes requires supplementation to restore and maintain it.

Healthy human microbiome (a collection of thousands beneficial bacteria living on and in our body) is of the critical factors in our natural defense against disease. Taking probiotics helps to restore the balance of good bacteria.

Probiotics

There are several strains that have been studied for their effectiveness against recurrent UTIs.

Probiotics work in three main ways when it comes to UTI prevention:

  1. Increased number of good bacteria in your gut allows for better nutrient and vitamin production, that in return improves how our body functions and resists infection
  2. Healthy vaginal flora helps preventing pathogenic bacteria from reaching urinary tract
  3. Healthy flora in your bladder helps you to fight pathogenic bacteria.

To understand how to choose right probiotic strains that demonstrated clinical effectiveness in prevention of urinary tract infections, check out Probiotics & UTI: what do you need to know.

What other supplements are you taking to prevent UTIs? Leave me a comment!

5 COMMENTS

  1. Good article, and I love what you’re doing with your blog. I think it has help me immensely with a reoccurring UTI.

    If I may offer one piece of constructive criticism. A marshmallow (as you depict roasting over an open flame), and marshmallow root, are two very different things. I hope no one sees the image you posted and thinks they can get the same health benefits from eating a bag of sugary treats (marshmallows), as they would from taking marshmallow root supplements.

  2. Thank you! This is fantastic information. Would you recommend taking all of these simultaneously? I may have missed this in your blog but should they be taken for a certain amount of time and then stopped?

    • Hi Mon, glad to hear it is helpful. Best answer is to consult with an MD. My personal opinion, depending on what is the reason for your UTIs. If this is, for example, due to catheter, then take it while you have it in. If trying heal after years of chronic UTI, I would stick with a supplement that works for at least a year. In some cases you can take supplements after a trigger event (after sex, or after eating aggravating food) etc..
      I would not recommend taking all of them simultaneously, but would suggest to consider taking a supplement from each category till you figure what protocol works for you.
      Best of luck,

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