6 Worst D-MANNOSE Mistakes. D-Mannose Dose For UTI. How To Take D-Mannose

According to Dr. Wright who was the first physician to use D-Mannose in the USA in the 1980s, D-Mannose helps prevent and treat UTIs caused by E. coli bacteria. However, it’s important to note that the FDA does not support his statement and recognizes D-Mannose only as a supplement that is not intended to prevent or treat UTI.

At the same time, the treatment of UTI with D-Mannose has a solid theory behind it and some successful clinical research studies that have demonstrated D-Mannose effectiveness for UTI prevention (this one: D-Mannose is as effective as antibiotics in UTI prevention and this one). D-Mannose is also a pretty safe and has only a few manageable side-effects.

What’s D-Mannose?

D-Mannose is actually a type of sugar. But not your regular sugar (glucose), which goes with your coffee (this type would actually make your symptoms worse).

Instead, your body does not metabolize D-Mannose like other sugars. That’s why D-Mannose does not affect the blood sugar levels, and therefore is safe for the diabetics.

This is also why once you intake D-Mannose it is quickly expelled from your body in urine.

Maintaining a high concentration of D-Mannose in urine is a key way to fight an E. coli bacterial growth in your bladder.

So you might wonder why your doctor never mentioned D-Mannose, and that’s a legitimate question.

Why My Doctor Doesn’t Know About D-Mannose?

First of all, most physicians follow official treatment guidelines, otherwise, they are just asking for legal trouble.

Second, D-Mannose doesn’t always work as well as antibiotics, as it’s a natural substance and the quality, therefore, varies.

Third, clinical trials that would require a re-classification of D-Mannose as a drug are prohibitively expensive, and given that D-Mannose is naturally occurring, there is no interest on behalf of big pharma to sponsor such trials (because they can’t patent it and then return the money they borrowed to pay for such trials).

It’s ironic, that many physicians still recommend cranberry juice for UTI that has been proven not effective for UTI prevention while having no idea about D-Mannose.

UTI Prevention Is Better Than Cure

While D-Mannose is a great supplement, it’s only one part of the solution. Do you want to prevent UTI naturally, without antibiotics? Most likely you’ll need a range of strategies to:

Key Points: How To Take D-Mannose. D-Mannose Dose for UTI 

  • Buy D-Mannose in powder instead of capsules. One of the best “bang for the buck” options on Amazon is BulkSupplements Pure D-Mannose Powder.
  • Drink half of glass of water with your first D-Mannose dose (1 teaspoon 2-3 hours for treatment supplementation)
  • Take D-Mannose as early a possible before the infection fully develops
  • Don’t self-treat for longer than two days
  • If you have a corn allergy, here are D-Mannose options that are not made from corn: Pure Encapsulations – d-Mannose Powder.
  • Keep in mind, E. coli are responsible for 90% of all urinary tract infections, the rest could not be cured by D-Mannose.

Common Mistakes When Taking D-Mannose

#1 Common mistake: Drinking your first dose of D-Mannose with a lot of water

If you just ingested D-Mannose, wait a moment before drinking a lot of water. If you are drinking too much water right away, you are diluting the concentration of D-Mannose in your bladder, thereby cutting down its potency.

  • Take your dose with no more than half of a glass of water
  • Then wait for about 45 mins to an hour
  • After that, drink plenty of water in order to get rid of harmful bacteria.

This way concentrated D-Mannose has more time to bind to E. coli bacteria before you flush them with water.

#2 Pricey mistake: Buying D-Mannose in capsules

Do not overpay by buying D-mannose capsules. You’ll not only be wasting your money but also ingesting all the extra ingredients that are required for processing the powder into capsules (for example rice flour, stearic acid, magnesium stearate and silica).

You can measure D-Mannose powder with a teaspoon, but don’t worry: you do not have to be precise.

The powder has a pleasant, sweet taste, and when you add D-Mannose to water, it dissolves easily.

#3 Dangerous mistake: Waiting too long before seeing a doctor

If you decided to treat your UTI with D-Mannose, know that you are assuming certain health risks, though they are not associated with D-Mannose itself.

The main side-effect risk is that D-Mannose won’t work for you and your UTI bacteria could ascend to your kidneys, which is a very serious infection. Best is to watch your symptoms closely and do not rely entirely on an OTC UTI test that could misfire.

Learn about the main D-Mannose side effects and how to avoid them.

If your UTI symptoms have not diminished or completely disappeared after 1-2 days, do not wait any longer and go to the doctor.

Remember, D-Mannose only works for UTIs caused by E. coli bacteria, and if you let your infection go untreated, you are at risk of developing a dangerous kidney infection, or even deadly sepsis.

If you are experiencing frequent UTIs, there is a higher chance that your infections are caused by multiple bacteria types, not only E.coli.

Scientists still don’t know why for some suffering UTIs caused by E. coli, D-Mannose is a miracle cure, but for other patients, it simply doesn’t work.

One point to remember is that D-mannose is a natural product and it’s possible that variations in sources and methods of manufacture, as well as a diversity of pathogenic bacteria, could play a role.

#4 Taking D-Mannose too late

It appears that D-Mannose works best if taken preventively or at the very first signs of infection.

A full-blown UTI might benefit from D-Mannose supplementation, but you are running a risk that bacteria are growing at a faster rate than you are able to clear them.

If you end up taking antibiotics, supplementing with D-Mannose could be an option to speed up recovery, but do not stop your antibiotic treatment to switch to D-Mannose. You’ll be running a risk to develop a drug-resistant bacteria.

#5 Relying only on D-Mannose for your UTI treatment strategy

I understand your desire to stick with a natural supplementation for your UTI prevention and treatment needs.

However, UTIs (especially chronic ones) are a multi-faucet problem requiring a complex approach.

Thankfully, there are plenty of herbal and natural remedies to help you stay healthy!

If this is your first UTI, don’t wait for it to turn into a chronic problem. Contracting a UTI might be a warning signal from your body about other imbalances (vaginal flora, hormones, stones etc..).

#6 Buying D-Mannose made from corn if you are allergic to corn

Did you know that most of the D-Mannose products are made from corn? If you are allergic to corn, usual D-Mannose side-effects could be further exacerbated by your allergy reaction to D-Mannose (hives, GA troubles).

If you know or suspect that you might be allergic to corn, be sure to choose D-Mannose made from cranberries or pineapple.

D-Mannose Dose For Acute UTI

Consider this when trying to supplement your UTI treatment with D-mannose:

  1. Try the typical D-Mannose dose for UTI treatment: 1500-2000 mg (capsule form) or one-half to one teaspoon (powder) in a half glass of water every two to three hours for five days.
  2. Drink plenty of water in between D-Mannose doses.
  3. Remember that as of now, no one has clinically tested and established the exact quantity and frequency of D-Mannose for UTI treatment.
  4. Different people will react differently to the same D-Mannose dose (depending on their age, weight, overall health).
  5. The quality and purity of D-Mannose could vary from one manufacturing company to another, and even from one batch to another!
  6.  D-Mannose has certain side-effects and it’s important to weigh all pros and cons before you try it.
  7. Be careful which D-Mannose brand you chose if you are allergic to corn.
  8. Once you have started taking D-Mannose, UTI symptoms should significantly diminish within the first 48 hours, but keep it up for 2-3 more days even if the symptoms are gone. If your symptoms did not diminish within the first day, see a doctor immediately.
  9. Normally, one 50g dose (2-3 ounces) of D-Mannose is sufficient (most likely that’s how much you’d have in one package) for one course.
  10. Some find it beneficial to follow up an acute episode of a UTI with a month of preventive D-Mannose dose taken daily.
  11. Consult with your physician on how to supplement your UTI treatment with D-Mannose.

D-Mannose Dose For UTI Prevention

I take D-Mannose after certain trigger events that could cause my UTIs. Consider this when adding D-Mannose to your UTI prevention strategy:

  1. For UTI prevention take 1500-2000 mg (or one-half teaspoon) once or twice a day.
  2. You can take “preventive” dose safely for as long as you want. Your bacteria won’t develop a resistance.
  3. Ladies, take D-Mannose every time you think your vaginal flora is compromised (with the first signs of yeast infection, when consuming a lot of sugar, during stressful times, after sex, etc.).
  4. Check out my other home remedies for UTI.

D-Mannose products: Best value for the buck

The more volume you buy, the less you pay!

Compare to:

Here are some more expensive D-Mannose brands that are not made from corn, and produced in the USA from cranberries and pineapples:

Read my full 2018 review of popular D-Mannose supplements that allows you to compare brands to understand which D-Mannose will last longer if you are taking it for prevention.

FAQs About D-Mannose & UTIs

Is D-Mannose suitable for children?

Well, at the end of the day, it is only a type of sugar—and not the harmful type! At the same time, the doses should be adapted according to age and weight. However, keep in mind that there is a rare genetic disease that messes up how this type of sugar (mannose) is produced and absorbed by your body. Make sure to educate yourself about it before treating yourself or your child.

Moreover, kids normally get UTIs because of urine retention or backward urine flow. It is important to diagnose them for the underlying issues causing the infection instead of trying to self-treat.

Definitely, do not use D-Mannose instead of antibiotics if kids are too young to report their symptoms. It is better to not experiment with any natural supplements and follow your doctor’s advice.

If your child is already taking an antibiotic, you can try to supplement it with D-Mannose. Be extra careful with the dosage, as too much can cause diarrhea.

Is D-Mannose suitable for diabetics?

D-Mannose is most likely suitable for diabetics. Since only very small amounts of D-Mannose are metabolized by the body, it won’t typically raise your sugar level.

Nonetheless, sugar levels in the blood should be monitored regularly. We still don’t know enough about D-mannose metabolism, so you should exercise caution.

How soon to expect a relief with D-Mannose?

If you started taking D-Mannose at the first signs of a UTI you would typically notice a drastic reduction in symptoms as soon as 24 to 48 hours. However, if you do not notice an improvement in your symptoms, make sure to see your physician right away.

An untreated UTI could turn into a dangerous kidney infection and even a lethal sepsis. Every time you choose to self-treat you are running a risk.

Moreover, D-Mannose supplements can also be taken for UTI prevention without damaging your natural digestive and vaginal flora, a benefit that antibiotics cannot provide.

D-Mannose and FDA: Important disclaimer

D-Mannose is a popular supplement among UTI sufferers who are looking for a natural solution to prevent and treat urinary tract infections (just scroll down the page to read comments from the readers like you!).

Anecdotal evidence is growing and contributing to the Internet hype about D-Mannose products since we all want to find a cure from UTI.

However, D-Mannose is a food supplement and FDA does not regulate it. A dietary supplement product is not able to claim it can be used to “diagnose, treat, cure or prevent any disease,” because only a drug can legally make such a claim. There is not enough scientific evidence that D-Mannose can treat a UTI, therefore, try it at your own risk and closely monitor your symptoms.

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380 thoughts on “6 Worst D-MANNOSE Mistakes. D-Mannose Dose For UTI. How To Take D-Mannose”

  1. Damaris Ramirez

    Hello ! My granddaughter has Kidney hydronephrosis, as a result she suffers from concistent UTI’s and she is only one year old. Base on my experience, D mannose has been a great success with my UTIS and I honestly can say that I haven’t seeing one since I started using D mannose . My question will be , It is safe to use D mannose in children ? I have been telling my son to start using D mannose but his concern is that she is too little . Need help please ?

    1. Damaris, I wish I could help, so sad the little one has to struggle with UTIs. Unfortunately, I’m not a medical professional and can only point you towards information. I’d suggest checking out this interview with Dr. Wright and see if he can recommend somebody in your area or if he can do an online consult, I think an experienced naturopath could be an option for you to check out. Best wishes,

    2. I would definitely not give D-Mannose to a child. I read lots of reviews and they all talked glowingly about this supplement. And I believe they worked for all these people (on Amazon). However, I tried D-Mannose this week for a UTI infection and after 2 doses 3 hours apart (only 2) I had such a stiff neck a couple of hours later that I thought I had meningitis. It has taken me 24 hours for my neck to return to normal. I stopped after 2 times and decided if I do take it again and I might try it in the futue, I will begin with only one half teaspoon once a day or perhaps every other day to find out if I again experience a very stiff neck. It was a wierd stiff neck also, I was petrified actually, Because I couldn’t turn my head at all. I knew that I was because of the D-Mannose and whatever was in it I need to be very careful. The nausea I had been having briefly went away but it returned. So not totally counting it out, but I will be extremely careful in taking it in the future and will go very very slowlly. I just want to find out if it really does work even if I take a lesser amount. I am used to taking supplements, but I have never had a reaction anything like this one. Just wanted to warn people, be careful. For me, it was almost a disaster, had I perhaps taken 3 or 4 dosages.. Do not want to scare anyone, just be cautious. I love supplementation, but on this one, I did not know I would get the reaction I had. It will make me super cautious again, not sure if I will take any more or not. Still have the U.T.I. but am taking Azo now 4 per day with no bad effects and seems to be helping.

      1. Anastasia Visotsky

        Thanks so much, Patricia! Very unusual side-effects but glad you shared. Maybe, also consider switching the brand of D-Mannose. Hope you are feeling better,

  2. Should I take D-mannose separate of other supplements (meaning, should I wait to take it by itself)? Also, is it ok to take it with food, or is it more effective to take it separately?

    1. Hey there. There is very little research done on this, so every naturopathic doctor will have their own preferred method, you can also follow the manufacturer guidelines. In general, if you want a supplement to absorb faster and if it is not irritating to the stomach, it is a good idea to take it between meals (my personal nonmedical opinion). Some supplements are known to benefit from being consumed with certain foods (for example, vitamin D and oil, carotene and oil, probiotics and prebiotics + dairy etc..). I have not come across any info that would indicate the increase the effectiveness of D-Mannose if taken with food, so for faster absorption, I would personally take it on empty stomach with some water.

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