6 Worst D-MANNOSE Mistakes. D-Mannose Dose For UTI. How To Take D-Mannose

According to Dr. Wright who was the first physician to use D-Mannose in the USA in the 1980s, D-Mannose helps prevent and treat UTIs caused by E. coli bacteria.

Since the1980s several clinical studies have demonstrated D-Mannose effectiveness for UTI prevention (for example, this one: D-Mannose is more effective than antibiotics in UTI prevention).

However, you might wonder why your doctor never mentioned D-Mannose, and that’s a legitimate question. Short answer: D-Mannose is a natural product that you can’t patent and therefore will never make a fortune.

Summary of the post: 6 Worst D-MANNOSE Mistakes. D-Mannose Dose For UTI. How To Take D-Mannose:

  • Drink half of glass of water with your first D-Mannose dose (1 teaspoon 2-3 hours for treatment supplementation)
  • Buy D-Mannose in powder instead of capsules
  • Take D-Mannose as early a possible before the infection fully develops
  • Don’t self-treat for longer than two days
  • One of the best “bang for the buck” options on Amazon is BulkSupplements Pure D-Mannose Powder.
  • If you have a corn allergy, here are D-Mannose options that are not made from corn: Pure Encapsulations – d-Mannose Powder.
  • Keep in mind, E. coli are responsible for 90% of all urinary tract infections, the rest could not be cured by D-Mannose.

While D-Mannose is a great supplement, it’s only one part of the solution. Do you want to prevent UTI naturally, without antibiotics? Most likely you’ll need a range of strategies to:

What’s D-Mannose?

D-Mannose is actually a type of sugar. But not your regular sugar (glucose), which goes with your coffee (this type would actually make your symptoms worse).

Your body does not metabolize D-Mannose like other sugars. That’s why D-Mannose does not affect the blood sugar levels, and therefore is safe for the diabetics.

This is also why once you intake D-Mannose it is quickly expelled from your body in urine.

High concentration of D-Mannose in urine is the main reason why it works against E. coli bacteria in your bladder.

#1 Common mistake: drinking your first dose of D-Mannose with a lot of water

If you just ingested D-Mannose, pause and wait before drinking a lot of water. If you are drinking too much water right away, you are diluting the concentration of D-Mannose in your bladder.

Here is how you do it:

  • Take your dose with no more than half of a glass of water.
  • Then wait for about 45 mins to an hour.
  • After that, drink plenty of water in order to get rid of harmful bacteria.

This way concentrated D-Mannose has more time to bind to E. coli bacteria before you flush them with water.

#2 Pricey mistake: buying D-Mannose in capsules

Do not overpay for buying capsules.

You can measure D-Mannose powder with a teaspoon: don’t worry, you do not have to be precise.

The powder has pleasant sweet taste and when you add D-Mannose to water it dissolves easily.

If you buy D-Mannose in capsules, you are not only wasting your money but also ingesting all extra ingredients that are required for processing the powder into capsules (for example rice flour, stearic acid, magnesium stearate and silica).

#3 Dangerous mistake: waiting too long before seeing a doctor

If you decided to treat your UTI with D-Mannose you are assuming certain health risks. These risks are not associated with D-Mannose itself. Although D-Mannose does have side-effects, the main risk is that D-Mannose won’t work for you and your UTI bacteria could ascend to your kidneys.

Learn about main D-Mannose side effects and how to avoid them.


Therefore, if your symptoms have not diminished or completely disappeared after 1-2 days, do not wait any longer and go to the doctor.

Remember, D-Mannose only works for UTIs caused by E. coli bacteria, and if you let your infection go untreated you are at risk of developing a kidney infection, or even a deadly sepsis.

If you are experiencing frequent UTIs, there is a higher chance that your infection is caused by multiple bacteria types, not only E.coli.

Scientists still don’t know why for some D-Mannose is a miracle cure, but for other patients who as well have a UTI caused by E.coli, D-Mannose simply doesn’t work.

It’s a natural product and it’s possible that variations in sources and methods of manufacture, as well as a diversity of pathogenic bacteria, could play a role.

#4 Taking D-Mannose too late

It appears that D-Mannose works best if taken preventively or at the very first signs of infection.

A full-blown UTI might benefit from D-Mannose supplementation, but you are running a risk that bacteria are growing at a faster rate than you are able to clear them.

If you end up taking antibiotics, supplementing with D-Mannose could be an option to speed up recovery, but do not stop your antibiotic treatment to switch to D-Mannose, you’ll be running a risk to develop a drug-resistant bacteria.

#5 Relying only on D-Mannose for your UTI treatment strategy

I understand your desire to stick with a natural supplementation for your UTI prevention and treatment needs.

However, UTIs (especially chronic ones) are a multi-faucet problem requiring a complex approach.

Thankfully, there are plenty of herbal and natural remedies to help you stay healthy.

If this is your first UTI, don’t wait for it to turn into a chronic problem. Contracting a UTI might be a warning signal from your body about other imbalances (vaginal flora, hormones, stones etc..).

#6 Buying D-Mannose made from corn if you are allergic to corn

Did you know that most of the D-Mannose products are made from corn? If you are allergic to corn, your reaction might be similarly upsetting when you take D-Mannose (hives, GA troubles).

If you know or suspect that you might be allergic to corn, choose D-Mannose made from cranberries and pineapple.

D-Mannose Dose For An Acute Infection

Consider this when trying to supplement your UTI treatment with D-mannose:

  1. Try the typical D-Mannose dose for UTI treatment: 1500-2000 mg (capsule form) or one-half to one teaspoon (powder) in a half glass of water every two to three hours for five days.
  2. Drink plenty of water in between D-Mannose doses.
  3. Remember that nobody has yet clinically tested and established the exact quantity and frequency of D-Mannose for UTI treatment.
  4. Different people will react differently to the same D-Mannose dose (depending on their age, weight, overall health).
  5. Quality and purity of D-Mannose could vary from one manufacturing company to another, and even from one batch to another!
  6.  D-Mannose has certain side-effects and it’s important to weigh all pros and cons before you try it.
  7. Be careful which D-Mannose brand you chose if you are allergic to corn.
  8. Once you have started taking D-Mannose, UTI symptoms should significantly diminish within the first 48 hours, but keep it up for 2-3 more days even if the symptoms are gone. If your symptoms did not diminish within the first day, see a doctor immediately.
  9. Normally, one 50g dose (2-3 ounces) of D-Mannose is sufficient (most likely that’s how much you’d have in one package) for one course.
  10. Some find it beneficial to follow up an acute episode of a UTI with a month of preventive D-Mannose dose taken daily.
  11. Consult with your physician on how to supplement your UTI treatment with D-Mannose.

D-Mannose Dose For UTI Prevention

I take D-Mannose after certain trigger events that could cause my UTIs.

Consider this when adding D-Mannose to your UTI prevention strategy:

  1. For UTI prevention take 1500-2000 mg (or one-half teaspoon) once or twice a day.
  2. You can take “preventive” dose safely for as long as you want. Your bacteria won’t develop a resistance.
  3. Take D-Mannose every time you think your vaginal flora is compromised (with the first signs of yeast infection, when consuming a lot of sugar, during stressful times, after sex, etc.).
  4. Check out my 8 Holistic Strategies to Prevent UTI Naturally here.

 D-Mannose products: best value for the buck

The more volume you buy, the less you pay!

Compare to:

More expensive D-Mannose that is not made from corn, and produced in the USA from cranberries and pineapples. Also, this type of D-Mannose tends to be pricier:

Read my full 2018 review of popular D-Mannose supplements that allows you to compare brands to understand which D-Mannose will last longer if you are taking it for prevention.

Is D-Mannose suitable for children?

Well, it is only sugar! At the same time, the doses should be adapted according to age and weight. However, there is a rare genetic disease that messes up how mannose is produced and absorbed by your body. Make sure to educate yourself about it before treating yourself or your child.

Moreover, kids normally get UTIs because of urine retention or backward urine flow. It is important to diagnose them for the underlying issues causing the infection instead of trying to self-treat.

Definitely, do not use D-Mannose instead of antibiotics if kids are too young to report their symptoms. It is better to not experiment with any natural supplements and follow your doctor’s advice.

If your kid is already taking an antibiotic, you can try to supplement it with D-Mannose. Be extra careful with the dose to not cause diarrhea.

Is D-Mannose suitable for diabetics?

D-Mannose is most likely suitable for diabetics. Since only very small amounts of D-Mannose are metabolized by the body it won’t typically raise your sugar level.

Nonetheless, sugar levels in the blood should be monitored regularly. We still don’t know much about mannose metabolism and you should exercise caution.

How soon to expect a relief with D-Mannose?

If you started taking D-Mannose at the first signs of a UTI you would typically notice a drastic reduction in symptoms as soon as 24 to 48 hours. However, if you do not notice an improvement in your symptoms, make sure to see your physician right away.

An untreated UTI could turn into a dangerous kidney infection and even a lethal sepsis. Every time you choose to self-treat you are running a risk.

Moreover, D-Mannose supplements can also be taken for UTI prevention without damaging your natural digestive and vaginal flora, a benefit that antibiotics cannot provide.

D-Mannose and FDA: important disclaimer

D-Mannose is a popular supplement among UTI sufferers who are looking for a natural solution to prevent and treat urinary tract infections (just scroll down the page to read comments from the readers like you!).

Anecdotal evidence is growing and contributing to the Internet hype about D-Mannose products since we all want to find a cure from UTI.

However, D-Mannose is a food supplement and FDA does not regulate it. A dietary supplement product does not “diagnose, treat, cure or prevent any disease,” because only a drug can legally make such a claim. There is not enough scientific evidence that D-Mannose can treat a UTI, therefore, try it at your own risk and closely monitor your symptoms.

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  1. Hi Anastasia V

    Hope you are good at health. I just wanted to know that is there any relationship between D- Mannose and Alkaline medium in UTI

  2. Hi Anastasia,

    I’m so relieved that I have found your website. I’ve looked over some of your articles before but in light of my circumstances and the wealth of knowledge you seem to have accumulated I will definitely be digging into it deeper. It’s also great to see how interactive you are with people who have problems.

    I got my first kidney infection about the time I first had sex which was several years ago. (I had one previous uti when I was about 11 but nothing besides.) After that I had a couple more infections, which seemed to bounce back between lower uti symptoms and flank pain, but I could wash it out with water about half the time before I had to see a doctor. This went on for a year or two, then I didn’t have sex for about 7 months and during that time I didn’t have one uti after I took an antibiotic to clear the last kidney infection.

    Almost a year ago I got into my second serious relationship and started having sex with the same problem as before. I know kidney infections are serious and I’m trying to see a specialist but it’s been a slow process changing health insurance plans and then having possible allergic reactions to antibiotics.

    I’ve tried D-mannose before, I went through three or four bottles with no effect so I pretty much gave up on it. I’ve been thinking of trying it again as more of a preventative measure each time I have sex. It’s terrible to think of not sharing this with my partner. Last time I had a kidney infection it was E-coli. I was wondering if you have any more advice, because if I can curb the utis I don’t think I will get the kidney infections. (Also I think I’ve had yeast infections since I was about 16, which I’m now realizing could play a role in this.)

    • Hi Alisha, thank you for your kind words. Remember, I’m not a medical professional, just a fellow UTI-nerd 🙂 I think your insight about yeast infections is right on the money. Have you ever looked at what is the reason? Hormonal issues? Diet? Maybe check in with a good naturopathic doctor to get that under control. Here are couple posts that could be useful, I’d start by looking at this one: vaginal discharge and UTI and vaginal probiotics. Here is an interesting interview with Dr. Hawes, there is a bit about diagnosing kidney infections which was eye-opening fo me. And here is a recent interview with Dr. Wright, not sure if you have seen it.
      Best wishes,

  3. Oh one other thing .. have you ever seen an Osteopath? They use natural body manipulations for somatic dysfunctions. I always took my kids to Osteopath first and if they couldn’t fix them then the doctor.. but for me personally, Osteopathy has been a God send. Again, good luck on your search for health and wholeness.

  4. Dear Anastasia,
    I’ve recently got a UTI about a week ago, last last friday and I started using D-mannose to see if it would help with it as I’ve heard god things about it. About a few hours after taking my first dose I noticed I got quite an upset stomach, which then turned into being very painful. I slept it off that night but then got it again the next day. I continued taking D-mannose as it was helping my UTI while taking pain relief for my upset stomach. Just wondering if this is a common side affect of D-Mannose? I’m also wondering if D-Mannose affects birth control (the pill), as this could be giving me an upset stomach?

    Thank you, Bre

  5. Dear Anastasia,

    I’m in dire need of help! My life has been total chaos since january this year, I’m incredibly depressed and losing hope I will ever get past this. I’m losing everything… I’ve been in and out the doctor office and ER so many times since january that I have lost count!

    On january, after several weeks of pain and suffering, a doctor gave me Monuril 3000 for a UTI, it worked, but I got incredibly sick afterwards. I was finally free from infection, or so I thought. They sent me to see the urologist, he did a cystoscopy to find out why I was still peeing a lot (I spent a whole night peeing every 10 minutes even though I barely drank anything in between). They found the source: the infection had irritated a very sensitive area in my bladder. He put me on a prophylactic treatment for 30 days. Two days after finishing the treatment the UTI came back again 🙁

    I feel terrible, because I feel that taking that prophylactic treatment was a mistake. Same goes for the cystoscopy. I wish I had found your site earlier 🙁 Sadly it wasn’t until 2 weeks later that the doctor gave me antibiotics, and by that time I already had pain in my left kidney! It’s a 7 day course, and tomorrow will be finished. The doctor didn’t want to give me antibiotics earlier because the urine test was negative, she just ignored my symptoms!

    I’m terrified, I don’t want to go through this again. What dose D-mannose would you recommend for someone in my situation?

    I wish I could have written this earlier, but sadly I got sick with viral bronchitis on top of this! It’s been like a domino effect, I’ve already lost 6 kilos in the last 2 and half weeks due sickness (long story, the side effects of the antibiotics have been brutal). Please help me, I’m terrified!!!! I don’t think I can endure going through this again… my GP doesn’t even believe me!

    • Hi Karen, I’m so sorry to hear, it must have been pretty overwhelming. First of all, here is a long post about root causes of UTI and steps to address them , maybe start there and then join our FB group if you have more questions. I’d go with the same D-Mannose dose as described here, there is no need to increase it. It either works (if you have a certain type of e.coli) or not but in the post that I’m linking you would be able to find lots of ideas. Obviously, if starting new supplements it’s better to check with your doctor. Do look into NAC, especially given your bronchitis.
      You’ll be fine, I’m sure 🙂 Talk to you soon,

      • Thank you very much for the quick reply. It feels so good to talk with someone who understands what this is like, god bless you, Anastasia.

        I will read what you recommended, I’m trying to read everything I can from your blog! It’s pure gold! I can’t express how thankful I am for all the information you have gathered. It’s amazing! Finding your blog was like finding a bright light in the middle of a very dark & deep abyss, it gave me and still gives me a lot hope things will be ok.

        I already sent a request to join your group on Facebook 🙂

        I’ve an appointment with the urologist later this month. I’ll talk with him about NAC. I’m a bit afraid to ask, but something you wrote made me wonder: Doesn’t D-mannose work against most e-coli strains or only a specific one?

        • Hi Karen, you are most welcome. And thank you for your kind words, I’m happy if this information could help you to have a more informed discussion with your doctor.
          As to D-Mannose, it works with E.coli that are pathogenic (the ones that otherwise would stick to your bladder). These are the bacteria that grow pili (little tentacles) that allow them to grab on to naturally occurring mannose on your bladder walls. If E.coli bacteria do not have those pili they can’t cause a UTI either.
          Speaking of NAC, your doc most likely has never heard of it. I’d suggest printing out info from pubmed directly and asking him if he is OK to let you try it. The supplement has been extensively used for over ten years and has an excellent safety profile. From what I observed, naturopathic docs are the only ones starting to use it for UTI.
          Talk to you soon,

    • Hi,

      have you tried drinking STRAIGHT up non-sweet cranberry juice before bed and holding it for at least on hour if you can. They say the important part is to have the d-mannose in your bladder long enough for it to attach to the bacteria. Also I think D-Mannose is only good for e-coli and even tho e-coli is most common in UTI’s, there are other bacteria that cause UTIs. I hate to hear of anyone going through such pain. I hope you find what you need to heal quickly and permanently. I truly do.



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